Adapalene: Effective Skincare Ingredient

Cutting-edge ingredients require cutting-edge research. Our Clinical Advisory Board and Dermatology Team keep on top of the latest evidence to make sure our personalized formulas are the best they can be.

Guidelines of care for the management of acne vulgaris

Journal of the American Academy of Dermatology. Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, et al. 2016;74(5):945-73. e33.
A review of the use of adapalene for the treatment of acne vulgaris

Therapeutics and clinical risk management. Piskin S, Uzunali E, et al. 2007;3(4):621
A review of adapalene in the treatment of acne vulgaris

Journal of Adolescent Health. Irby CE, Yentzer BA, Feldman SR, et al. 2008;43(5):421-4
Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris

Ellis C, Millikan L, Smith E, Chalker D, Swinyer L, Katz I, et al. 1998
A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% gel in patients with acne vulgaris: a meta-analysis of five randomized trials

Cunliffe W, Poncet M, Loesche C, Verschoore M, et al. 1998
Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients

British Journal of Dermatology. Gollnick H, Draelos Z, Glenn M, Rosoph L, Kaszuba A, Cornelison R, et al. 2009;161(5):1180-9
Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study

SKINmed: Dermatology for the Clinician. Diane M T, Alan R S, Paul S Y, Catherine D, Stéphanie A, Sewon K, et al. 2005;4(3):138-46
A treatment for severe nodular acne: a randomized investigator-blinded, controlled, noninferiority trial comparing fixed-dose adapalene/benzoyl peroxide plus doxycycline vs. oral isotretinoin

British Journal of Dermatology. Tan J, Humphrey S, Vender R, Barankin B, Gooderham M, Kerrouche N, et al. 2014;171(6):1508-16
Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study

Archives of dermatology. Thiboutot DM, Shalita AR, Yamauchi PS, Dawson C, Kerrouche N, Arsonnaud S, et al. 2006;142(5):597-602
Daily treatment with adapalene gel 0.1% maintains initial improvement of acne vulgaris previously treated with oral lymecycline

European Journal of Dermatology. Alirezai M, George SA, Coutts I, Roseeuw DI, Hachem J-P, Kerrouche N, et al. 2007;17(1):45-51
Maintenance therapy for acne vulgaris: efficacy of a 12-month treatment with adapalene-benzoyl peroxide after oral isotretinoin and a review of the literature

Dermatology. Bettoli V, Borghi A, Zauli S, Toni G, Ricci M, Giari S, et al. 2013;227(2):97-102
Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Clinical interventions in ageing. Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G, et al. 2006;1(4):327
Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial

Journal of the American Academy of Dermatology. Kang S, Goldfarb MT, Weiss JS, Metz RD, Hamilton TA, Voorhees JJ, et al. 2003;49(1):83-90

Got questions about adapalene?

What is Adapalene?

Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and wrinkles.

Adapalene prevents breakouts, blackheads, whiteheads, blemishes and clogged pores as well while restoring skin tone and texture by clearing acne. Adapalene can help reduce the risk of scarring and hyperpigmentation by treating acne.

How does Adapalene work?

Adapalene improves and repairs the epidermal (hyperpigmentation and surface roughness) and dermal (fine wrinkles) layers in the skin. It also reduces excess propionibacterium acnes, the bacteria associated with acne development.

What are the side effects of using Adapalene?

All medications have some side effects so it is important to be aware, however, do not be alarmed as you may not experience them.

Many of the side effects associated with Adapalene last for only a short time and can resolve after a few weeks of use. Using a lower strength Adapalene product to begin with can reduce the likelihood of side effects.

Some of the most common side effects are:

dry and peeling skin
burning and stinging
irritation and inflammation
red, raised areas on the skin
rash or itching
change in skin colour
disturbance of the levels of enzymes in the liver (this is rare, however tell your doctor that you are using Adapalene.)

It is important to immediately stop use and go to your nearest hospital emergency department should you have an allergic reaction to Adapalene. Signs of an allergic reaction include a skin rash, itching, shortness of breath and/or a swollen face.

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Evidence-based ingredients

Adapalene

Adapalene

Targets

Strength

Evidence

Key benefits

Targets acne

Improves skin texture

Improve signs of aging

Understanding adapalene

Delving into the details

Show me the studies

Guidelines of care for the management of acne vulgaris

A review of the use of adapalene for the treatment of acne vulgaris

A review of adapalene in the treatment of acne vulgaris

Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris

A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% gel in patients with acne vulgaris: a meta-analysis of five randomized trials

Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients

Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study

A treatment for severe nodular acne: a randomized investigator-blinded, controlled, noninferiority trial comparing fixed-dose adapalene/benzoyl peroxide plus doxycycline vs. oral isotretinoin

Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study

Daily treatment with adapalene gel 0.1% maintains initial improvement of acne vulgaris previously treated with oral lymecycline

Maintenance therapy for acne vulgaris: efficacy of a 12-month treatment with adapalene-benzoyl peroxide after oral isotretinoin and a review of the literature

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial

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Got questions about adapalene?

What is Adapalene?

How does Adapalene work?

What are the side effects of using Adapalene?

Get industry-leading advice from skin experts

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