Dermatica - Smiling woman holding Dermatica bottle in the hand

The next generation of anti-aging prescription skincare

Get a personalized formula with active ingredients to reduce wrinkles, smooth fine lines and fade dark spots, with visible results within 12 weeks.

Start your free trial

Just pay a $4.99 prescribing fee.

Aging skin worries? A thing of the past

Dull skin
Fine line and wrinkles
Skin firmness

Aging skin worries? A thing of the past

Why does our skin age?

Everyone’s skin changes as we get older. Collagen production slows down, and factors like sun exposure, pollution and smoking will cause aging too. Visibly, we’ll notice fine lines, wrinkles, pigmentation, more noticeable pores and less elasticity.

Results you’ll love -
here’s the proof

Start your free trial

Just pay a $4.99 prescribing fee.

Evidence-backed active ingredients

Your formula has precisely measured prescription ingredients to slow and reverse visible signs of aging – and suit your skin.

The SmartBase

Your personalized formula is supercharged with powerful prescription ingredients and blended with our hydrating SmartBase cream, which contains hyaluronic acid, ceramides, glycerin and panthenol for best results.

Locks in moisture and softens illustration

Locks in moisture and softens

Nourishes your epidermis on multiple levels illustration

Nourishes your epidermis on multiple levels

Strengthens your skin barrier illustration

Strengthens your skin barrier

How it works

  1. reaching goal illustration

    Step 01

    Complete an online consultation

    This will help our dermatology experts prescribe the right formula for your skin

  2. designing treatment plan illustration

    Step 02

    Apply your formula once a night

    With the perfect combination of active ingredients for your unique skin.

  3. adapting treatment formula illustration

    Step 03

    Check in throughout your journey

    We’ll monitor your progress and adjust your treatment as needed.

Start your free trial

Just pay a $4.99 prescribing fee.

Dermatology, designed for you

Dermatology designed for you
  • A personalized formula, developed by experts

    You’ll get a personalized, evidence-based prescription treatment, tailored to your treatment goals.

  • Delivered to you every 56 days (approx.)

    Your bespoke plan arrives with two bottles every 56 days (approximately), and adapts to your skin’s progress.

  • 24/7 support

    You’ll have free, unlimited access to dermatology experts, whenever you need.

  • You’re in total control

    You can pause, reschedule or cancel your plan online. No strings attached.

First month $4.99

then $29.95/month

Support your treatment with our routine essentials

Our range of daily essentials were designed by dermatologists to work alongside active ingredients. Fragrance free, gentle and effective for all skin types.

Read what others say, in their own words

Showing our favorite reviews
“I love the personalized service & for a great price. I have been really impressed with the product - my skin looks great. It was easy to do the consultation & the retinol cream has been a pleasure to use. It started on a lower % of 0.25 & is now 0.5. Fantastic.”
Sara Caistor
Verified Facebook review
“Amazing service. Brilliant product that I used to pay hundreds of pounds for and amazing results. Tailored to my own skin problems and I can’t recommend Dermatica enough. Easy to cancel if you’re not happy but I guarantee you will be so pleased with the results you will carry on just as I have 😊😊”
Claire Smith
Verified Google review
“Having tried many products before to help with my skin I can honestly say that I have been very impressed with skin is probably the best it has been in years. Getting the formula was simple enough and the results speak for themselves. Worth every penny.”
Erin Beale
Verified Facebook review
“My skin has been the best it's ever been since I was a teenager my pigmentation has significantly cleared and acne has been kept at bay. I will never use anything other than dermatica I am so relieved I found this brand and have recommended to others. I receive compliments on how good my skin looks it's taken years off me.”
Verified review
“I am such a fan of Dermatica and their service. Very easy to manage your subscription but as someone with incredibly problematic skin (who last week got complimented by a stranger on it!) I wouldn't be without it. I truly believe prescription skincare offers so much more than all the creams and lotions you can buy OTC.”
Verified Mumsnet review
“I’ve been using Tretinoin for almost three months now, and I’m loving it. Great customer service, great results and I’m now up to my maximum dose. I’m definitely seeing some peeling, but nothing that wasn’t explained in the literature you receive with the product. It’s saved me an absolute fortune on skincare, as I used to buy every new product on the market that promised the earth and delivered nothing.”
Sarah Blackley
Verified Facebook review
“The initial process of having the assessment and getting my personalized formula was so fast. Shortly after I received my products which I love so much and it has only been 2 weeks. My major skin concern was uneven dull skin tone, enlarged pores and fine lines. My skin is so glowing like it has never been before! It just looks so healthy and feels so soft. I had a few acne marks which are now faded.”
Réka Bódi
Verified Facebook review
“Dermatica has completely revolutionised my skin care. I am now 63 but my skin has never looked so good or been so healthy. My monthly delivery has become a part of my life now and I will continue for as long as I am able. The service is also second to none. Any questions I've submitted have always been answered promptly and without fuss. I would highly recommend Dermatica to anyone who cares about looking their best for as long as possible.”
Verified review
“I have PCOS and have struggled with acne for over 10 years, and have tried what feels like every acne medication available. My skin has never been better than while using my personalized Dermatica treatment, and I'm so happy! The subscription service is also very convenient, so I never have to worry about running out or having to go to the pharmacy for it.”
Bella Duncan
Verified Facebook review
“Love Dermatica. My skin is bright and the large pores and blackheads on my nose have gone. I've been using it for 6 months with Dermatica controlling the strength of the creams supplied to suit. I must say it has saved me a fortune on buying stuff to try and it not working and I can now use basic cleanser and moisturiser.”
Verified Mumsnet review
Dr Catriona Maybury, Consultant Dermatologist
“We use active ingredients that reverse photodamage, soften fine lines, stimulate collagen production and improve skin texture. We create personalized formulas to work for all ages.”
Dr Catriona Maybury, Consultant Dermatologist
Start your free trial

Just pay a $4.99 prescribing fee.

Anti-aging FAQs

What is the difference between tretinoin and retinol?
Retinol, though similar in name, is actually weaker in strength than a retinoid. Both are derived from Vitamin A, but because retinols have a lower concentration than retinoids and are in a different form, it can take longer to see results. Retinols are readily available over the counter, whereas retinoids aren’t available over the counter. At Dermatica, we’re able to provide higher strength topical retinoids that aren’t available over the counter.
What's the best strength of tretinoin for anti-aging?
This depends on your skin type and your tolerance to tretinoin, so it will vary from person-to-person. To make sure your formula is right for your skin, we start patients at a low dose and increase gradually to avoid irritation. If you’ve previously been using a retinoid, you can let us know what strength and we’ll make sure your Dermatica treatment is working at its most effective level.
Can tretinoin improve deep lines such as naso-labial folds, elevens or marionette lines?
The appearance of deeper lines in our face can lessen or fade over time with treatment, however the results may take longer to see than with finer lines. As we age, our body produces less collagen and we can expect to lose some volume (plumpness) in our faces. While tretinoin is known to cause an increase in dermal collagen production, please note that topical treatment alone may not be enough to achieve your desired results with deeper lines. As aging is a continual process, the goal of topical treatment is often to prevent rather than reverse signs of aging.
Will my treatment help with wrinkles?
If your skin goal is to fade the appearance of fine lines and wrinkles, then we’ll carefully select powerful, science-backed active ingredients that should help smooth your skin and give you a more youthful look.

Retinoids are prescribed in Dermatica’s personalized formulas to restore dermal collagen, which improves fine lines. Niacinamide is often added as well to boost ceramide production, which increases hydration levels in your skin.

The ingredients in your formula are chosen by dermatology experts, and the strength will be adjusted as you continue your journey so you can get the best results. For deeper or larger wrinkles, while our active ingredients may improve the texture and appearance, you may need further treatment like fillers or Botulinum Toxin (botox) to fade them completely.

Get industry-leading advice from skin experts